I usually just turn camera angle to make it line up to arrangement of the buttons?? Doesnt order just depend on which way u r facing?? I am a button clicker though the relic dont seem to move so fast that I would really need to hot-key it... I am guessing this works better if you use hot-key??

i think if u use number but not color will better
topleft =1
topright =2
bottomleft =3
bottom right = 4

mabye when u doing this quest 1st time red is topleft
but doing next time it will change to bottom right

so i always look for where is red, where is yellow

we need to ignore color

Much needed adjustment, good work