Are you sure you're changing them in the right place? And what exactly are you trying to change? Size? Location? Rows & Columns or something else?
The correct path should be [ C: > Program Files > World of Warcraft > Interface > AddOns > nUI > Layouts > Default > nUI_Layout_Default_Dashboard.lua ] on a Windows XP machine or on a Windows 7 / Windows Vista machine it would be [ C: > Users > Public > Games > World of Warcraft > Interface > AddOns > nUI > Layouts > Default > nUI_Layout_Default_Dashboard.lua ]
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