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Addons shouldn't/don't have that kind of power over the system, unless theres a flaw in some of Blizzards LUA hooks (which we know Blizzard is perfect!)
Theres no difference between the two running, since even under Vista 64, WOW still runs in a 32 bit emulated mode so to the game, it is no different. I was having issues last night on Windows 7 x64, but it was because of some issues with battlegrounds, thus my character was stuck in limbo for a few minutes.
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