Hmmm... that's pretty odd... usually when that happens it's two buttons that are in the same place (side by side)
I know the voice chat frame is frequently a problem (I need to add that the managed frames list probably). If you enable voice chat in the interface/sound menu and press the voice chat key, it should "show" the voice chat frame -- it is overlapping those buttons? If so, you can just drag it out of the way.
Another way to identify the frame is to put your mouse over the area you cannot click and type in the command '/script print( GetMouseFocus():GetName() or "unnamed" )' -- what does it print?
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