I don't know if it matters any to say this... but this is a problem a lot of people using mods are having, not just nUI (FPS going to pot while in combat) -- it seems to have started with the WoW 3.0 patch and I still swear up and down that Blizzard broke something in the AddOn engine in that patch.
It does not affect everyone and I have yet to have found a pattern for it that would indicate a common cause.
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