As has been posted quite a few times now, and as was stated in the patch notes for 5.06.22 -- these updates are specifically for the 3.3.5 WoW patch. If you are playing on an Oceanic realm that has not yet been patched to 3.3.5 you *SHOULD NOT* use the 5.06.22 or 5.06.23 versions of nUI.
If you have installed either version on a realm that's not yet running 3.3.5 you will have a broken UI. You can roll back to an earlier version by going to
http://files.nUIaddon.com and going to the download page. Click the "Archived" tab and download 5.06.21 from there.