Hardly. I've gotten every "do X quests in this zone" achievement on every character I've leveled since Cataclysm, other than the ones I'm currently leveling with RAF bonuses, since I'm outleveling zones at about 25% completion. Every quest hub (except for a few in MoP, but those are all marked on the world map) has breadcrumbs, and the few quests that are picked up from random NPCs/objects out in the wild are easy to spot if you're paying any attention, since they have giant yellow question marks over them in the world and are marked on both the minimap and the world map.
If you somehow manage to "finish" a zone without getting its questing achievement, addons like
Wholly or
QuestHubber -- both of which I mentioned in my last post -- will be much more helpful than a guide, since you can just open your map and see the locations of any unfinished quest pickups at your convenience.