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You'll find that nUI6 is already "grid like" in its display of curses, magic, disease and poison and both nUI5 and nUI6 are compatible with the click-casting addon "Clique" which will allow you to do exactly what you're describing in terms of casting different spells based on the unit type and mouse button.
nUI6 will, eventually, allow you to do click-casting without using a mod, but for now Clique will do the trick for you.
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