Its all up to personal preference. Start with the question - "What don't you like about the default UI?"
For "me" - when I first started, I wanted to get rid of the gryphons on the sides of the bars. I wanted to see all of my bags in one big window instead of individual bags. Etc.
For hunters you might want some of Fizzwidget's mods - one will show you what trainable skills animals have. One will feed your pet with the push of a button.
Figure out what you want to change, then try a bunch of mods and settle in on what you like. No one can tell you!
Hope this helps guide you - don't be afraid - mods and not permanent - if things slow down to much just delete them!
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"I will crush and destroy and...ooo...shiny..."
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