If you did actually download oUF and the layout, then you need to open up the layout.lua file, go to near the bottom and look for the line
Code:
player:SetPoint("CENTER", -220, -295)
or something along those lines (I've already changed mine)
This controls where the player frame is. Ignore the first word for now. What you want to worry about are those 2 numbers. The first number is the X offset, the horizontal position. Negative values go towards the left, positive values towards the right.
The second number is the Y offset, the vertical position. Negative values go down, positive values go up.
You can change these numbers to make the frames go anywhere you want for all the different frames. (You should see target, pet, focus and tot below the player one)
NOTE: The focus, pet and tot frames are anchored to the player and target frames. This means wherever their anchor goes, these frames will follow them. So you really shouldn't need to mess with these ones.