there are many compilations on the site you can choose from. The include the mods needed to create the look they show. They also include custom SavedVariables folders (usually with instructions on how to install them) to more or less automatically set up the entire thing for you.
Just dig through the
Compilations and Suites section of the site and find one that suits you.
If you dont see one you like and are feeling frisky enough to make your own. there are many mods out there that can be used to create a custom and unique layout.
Using a mac doesnt really make much difference in the process, Just have to have a program that opens.zip files without corrupting them. I believe there is a forum on this around here somewhere ....(digs for forum)
Mac type discussion
That should answer all your questions.