Extra mouse button issues.

[Aeicor]

I use a R.A.T. 7 gaming mouse by MadCatz, and on it, it has 2 extra mouse buttons (4 and 5) I keybound these to commonly used abilities like interrupts and other things, and ever since 4.2, when I use these extra mouse buttons, my game doesn't freeze, but all the other abilities become unable to be clicked on (Yes, I am a clicker, sue me :P). I never had this problem prior to patch 4.2, and it only seems to be a problem with nUI, and yes I did disable all other addons and see if it was still bugged, and it wasn't.
Any help would be appreciated!