Not sure if this is a problem with nUI+ or with Clique.
Currently running latest release version of nUI+. After a few hours of play, or switching characters a few times, my click to cast bindings stop working on the nUI unit frames. The clique bindings still work on character name plates. My mouseover macros still work on the nUI unit frames.
Reloading the UI does not solve the problem. Quitting and restarting the game does solve the issue.