Pandora
 

Hey, i like listening to Pandora Radio while playing wow, and was wondering if it's possible to make an addon to control Pandora while playing in full screen, there are desktop apps, which i use OpenPandora, and the only features the wow app would need, is to be able to give thumbs up / down, pause, and next song. So, does anyone think this possible?

No, this is not possible. WoW runs in a sand-boxed environment, meaning that nothing gets in or out while it's running.

I use the mini player that comes with Songbird and have it 'always on top'. Works pretty nicely.