nUI6 does/will work easily with three monitors. All you would have to do is tweak the size and location of the UI and World frames in the layout file. You can put the UI on one screen and the world on the other two, or put the world frame on all three and limit the UI to any one of the three screens, etc. You just have to set up the boundaries of the world view and then where you want to locate the UI relative to it.
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