You got most of it well placed!
Centered and vertical(eye movement) for the important focus stuff is better for the eyes and head(widescreens). But repeatable stuff should be minimized(target debuffs etc.) a bit more.
Did you try move minimap and chat frame down instead of up?
Some eye thing again as i recall
When I say eyes etc. then the better placing of components, the less stress the eyes and head get which makes u able to focus better and longer...
Sounds like a potent pill commercial haha...