Looks good so far.
Suggestions:
1. Add more contrast between the health bar and its background, at least in screenshot #1; it looks fine in #2.
2. Filter the buffs. Do you really need an icon for Precious' Ribbon on your unit frames?
3. Do something with the portrait size. Either reduce the height so it lines up with the unit frame, or make it some fairly even multiple of the unit frame's height, like 2x or even 1.5x, and maybe center it vertically. Right now it's just a weird height, and it bothers me.
Based on my previous experience with oUF_Simple, though, my #1 suggestion would be to try to simplify the code. Every time I looked at it to try to help someone on the forums, I was pretty surprised anyone new to WoW programming could make heads or tails of anything in there, and would never have recommended it as a starting point for someone looking to write their own layout.
