For the Quest Objectives, (on the right by default), you can remove the fading in combat by editing Interface\AddOns\nibRealUI\Modules\ObjectivesAdv.lua line #142. Change the true value to false. Code should look like this afterwards:
Code:
combatfade = {
enabled = false,
opacity = {
incombat = 0.25,
hurt = .75,
target = .75,
harmtarget = 0.85,
outofcombat = 1,
},
},
If you edit this while the game is loaded you have to do a /reload for it to take effect. I have to do this every time because I forget and don't make the change every update. Would be nice if this was an option.