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Yes, removing addons you will never use will possibly prevent Mazzification. That's the short and simple answer. It's best to leave the addons in your Interface folder, Mazzify, and then disable the addons you don't use.
There are certainly plenty of addons that could be removed without issue, but unless you want to dig through the Mazzification code to see which addons aren't being configured in there then it would be guess and check to find out which ones can be removed.
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