function "has more then 60 upvalues"

[xConStruct]

Never encountered your message, but it seems like you're using a lot (over 60) of local variables which are then accessed by your OnUpdate-function which causes trouble.

As you create a lot of frames, you could try to store them in tables rather than locals - this would basically eliminate a lot of your upvalues as you're only accessing one in your function(the table).

In general, it would be more helpful to see some of your code or a description how you're creating/storing the frames.