ok after much messing about with this and trying all kinds of random stuff to get it to work, i found a bizzarely obvious and simple way to get the mazzifier to work... and here it is!
download both the main mazzle zip and the patch, extract the main archive to an empty folder, then extract the patch to the same folder. you should get a message asking if you want to replace folders with the same name and overwrite older files. DO IT! then rename your wow/interface/addons folder, make a new addons folder there and copy the contents of your patched mazzle folder here. go to your wow/wtf folder and rename the account folder.
log in, make sure 'load out of date addons' is checked and load up your char, then follow the mazzifier instructions. hopefully this should work
(it did for me anyway)
well good luck folks, i had a major headache getting this to work but it really is worth it!
wow 2.2.3 & windows vista