[MunkDev]

Haven't tried it, but maybe this works:

local button = CreateFrame("Button", "MouseoverButton", nil, "SecureHandlerStateTemplate, SecureActionButtonTemplate")
 
button:SetAttribute("type", "target")
button:SetAttribute("unit", "mouseover")
button:RegisterForClicks("AnyDown")
 
RegisterStateDriver(button, "mouseover", "[@mouseover,exists]true;nil")
 
button:SetAttribute("_onstate-mouseover", [[
    if newstate then
        self:SetBindingClick(true, "BUTTON1", self)
    else
        self:ClearBindings()
    end
]])