My Hunter is the only character I play where the default UI button placement isn't adequate. I found that I wanted a 3x12 block of buttons. The default of 2x12 + 12 at the bottom (and 12x2 on the side) was uncomfortable to me. I used
Dominos to configure a 3x12 at the bottom. I placed the pet bar, stance bar, and additional buttons on either side of the main block. I rearranged the pet buttons to put the ones I use close to the 3x12 block.
My son is using Dominos for all of his characters. I haven't found a need to switch on the rest of mine.
I also use Bitten's SpellFlash modules on some of the lesser played characters (I have all character modules loaded but I tend to ignore the suggestions and use my own rotation on the often played characters). I do like the flashing on the 60 minute buffs / poisons reminding me to renew them.