I like my Unitframes at the bottom of the screen so I can see more of the things that happen around me.
http://s.cdn.wowinterface.com/preview/pvw58391.jpg
The unitframes HP color gets more red if my life gets lower than 50%
Also there is a combattext in the middel of the screen.
Infight - I use buttoncooldows and timers so I most times look between bottom and middel of the screen.
Overall its just it's only a matter of getting used to it
